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Damage to the vagus nerve in diabetes mellitus is also the cause of a decrease in the tone of the NSP. Of the physiological conditions that cause a decrease in the tone of the esophageal sphincter, it is worth noting pregnancy. Increased relaxation of the lower esophageal sphincter.

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This happens with neurotic conditions, esophageal dyskinesia, systemic scleroderma, flatulence (bloating), diaphragmatic hernia, peptic ulcer and duodenostasis (food retention in the duodenum due to obstruction or decreased motility). Spontaneous relaxation of the sphincter is facilitated by hasty and plentiful food, the use of fatty meat and animal fats, flour products and bread, hot spices and fried foods. Violation of the motility of the stomach.

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For various reasons, hypomotility of the stomach develops, slowing down its emptying and prolonged overstretching of the organ, which causes stretching of the sphincter between the stomach and esophagus.

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Increased pressure inside the stomach, which contributes to throwing up. Weakening of protonix of the esophagus (dyskinesia of the esophagus) and slowing of the volumetric clearance of the esophagus (the ability to remove a chemical irritant from the esophageal cavity).

Also important is the violation of chemical clearance, when saliva does not have a neutralizing effect due to the fact that the content of bicarbonates in it decreases and saliva is produced in a smaller amount.

Dysfunction of the salivary glands appears with their diseases, esophagitis, diabetes mellitus, scleroderma, hypothyroidism, Sjögren's syndrome, toxic goiter, treatment with anticholinergics and in the elderly. Decreased resistance (resistance) of the esophageal mucosa to aggressive factors. Protective factors include. mucin, bicarbonates, nemucin proteins and prostaglandin E2.

Also, protection is provided by normal blood flow and the ability of the mucosa to quickly regenerate.

The presence of Helicobacter pylori in the mucosa of the cardial part of the stomach.

Hernia of the esophageal opening of the diaphragm.

Having listed all the reasons, it must be said that the main one is the failure of the lower esophageal sphincter, which is associated with neurovegetative disorders. Changes in esophageal clearance and motility of the esophagus, stomach, and duodenum are also often associated with disorders of the autonomic nervous system.

Injuries of the esophagus. Violation of pantoprazole pills and its quality.

Neuromuscular dysfunction of the esophagus, which develops after frequent exacerbations. Respiratory diseases (bronchial asthma, obstructive bronchitis). Increased pressure in the abdominal cavity with constipation, excessive physical exertion, heavy lifting, prolonged stay in an inclined position.

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